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It uses diindolylmethane to block estrogen, which is standard practice, but it uses some unconventional compounds to boost testosterone and to control cortisol levels as wellas to prevent estrogen from binding to the testes. But the results were disappointing. "We tried very hard to find a reason why the testosterone and cortisol levels did not improve after a week's treatment, but it turns out the reason is, of course, hormonal," says Tzchudi. The result is "an almost completely unresponsive test." "For a long time we thought that we could find an explanation for this," he says, so he and his colleagues took a closer look. Their research turned up evidence that the chemicals used in the experimental setup do not normally go into the body. This, Tzchudi says, means the study is not a proof-of-concept study but is only exploratory. Moreover, he emphasizes, it only shows whether the compounds that are used are safe, and nothing about whether they work. "We really wanted to show that the compounds would work," but the chemical used was more complex. The researchers had to change the way the compound worked so that it produced more effects than could be obtained with traditional, chemical-based solutions. "I think, ultimately, it is really exciting to be able to take this first step to demonstrate, with a very simple procedure, that there are certain, specific methods that can potentially be used to change testosterone levels or cortisol levels." He cautions, though, that the results should be seen in the context of what he and his colleagues have learned, and how they want to use the material in the future. "In order to show what we hope, that there are certain, specific protocols that can actually be used to change testosterone levels or cortisol levels, this is a very, very big step," says Tzchudi. "We feel very confident that we have demonstrated the concept behind it, and we think it will be very valuable in terms of future research." "This first step is something that all human studies of this type of treatment should be aware of. And Tzchudi, who had the idea to build this device while living and working in Germany, adds: "We wanted to make this tool as simple as possible. So, even if you are in Germany, you don't need to be a German, you can just download a version of this." To participate in the research at Stanford University, you need to fill out an informed consent form. The next steps will include submitting the completed form at a future open Similar articles: